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non-HLA DNA assays

Spanish translation: ensayos con muestras de ADN para detección/presencia de anticuerpos anti-HLA

00:08 Jan 17, 2016
English to Spanish translations [PRO]
Medical - Medical (general)
English term or phrase: non-HLA DNA assays
Estoy traduciendo un artículo titulado: "An evaluation of engraftment, toxicity and busulfan concentration in children receiving bone marrow transplantation for leukemia or genetic disease".

"Regimen-related toxicity (RRT) was evaluated using BMT criteria described by Bearman et al during the first 28 days post transplant and assigned a grade of 1 to 4. Engraftment was defined as an absolute ANC greater than 500 for 3 consecutive days with evidence of donor cells either by PCR for non-HLA DNA polymorphisms and/or in situ hybridization for X and Y chromosomes in sex-mismatched transplants. A quantitative estimate of engraftment (percent donor cells) was provided for sex-mismatched transplants. For **non-HLA DNA assays**, unique donor and recipient alleles were identified to assess full donor chimerism (sensitivity of 1–5%). For analysis, we included as ‘engrafted’ only those patients with 100% donor chimerism. Primary graft rejection was defined as no evidence of donor cells; secondary rejection was documented by initial evidence of donor engraftment followed by full autologous recovery. Engraftment was evaluated at 3 month intervals up to 1 year post BMT."

BMT = bone marrow transplant = trasplante de médula ósea
HLA = Human leukocyte antigens = antígenos leucocíticos humanos y se usan para determinar la compatibilidad entre donante y receptor de un trasplante
DNA = ADN

Muchas gracias nuevamente
Yvonne Becker
Local time: 17:26
Spanish translation:ensayos con muestras de ADN para detección/presencia de anticuerpos anti-HLA
Explanation:
No estoy segura, pero creo que por aquí van los tiros. Prefiero que lo investigues bien o esperar a recibir otras aportaciones.

Espero te sirva de algo. Saludos y feliz domingo.
Selected response from:

Margarita Ezquerra (Smart Translators, S.L.)
Spain
Local time: 23:26
Grading comment
Gracias. Al final coloqué: análisis de ADN que no sea de los antígenos de histocompatibilidad
4 KudoZ points were awarded for this answer



Summary of answers provided
2ensayos con muestras de ADN para detección/presencia de anticuerpos anti-HLA
Margarita Ezquerra (Smart Translators, S.L.)


  

Answers


12 hrs   confidence: Answerer confidence 2/5Answerer confidence 2/5
non-hla dna assays
ensayos con muestras de ADN para detección/presencia de anticuerpos anti-HLA


Explanation:
No estoy segura, pero creo que por aquí van los tiros. Prefiero que lo investigues bien o esperar a recibir otras aportaciones.

Espero te sirva de algo. Saludos y feliz domingo.

Margarita Ezquerra (Smart Translators, S.L.)
Spain
Local time: 23:26
Native speaker of: Spanish
PRO pts in category: 924
Grading comment
Gracias. Al final coloqué: análisis de ADN que no sea de los antígenos de histocompatibilidad
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