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Macrophages articulaires

German translation: synoviale Makrophagen/Makrophagen im Gelenk

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
French term or phrase: Macrophages articulaires German translation: synoviale Makrophagen/Makrophagen im Gelenk Entered by: Doris Wolf

08:45 Mar 31, 2020

French to German translations [PRO] Medical - Medical (general) / Rheumatologie
French term or phrase: Macrophages articulaires Hallo, ich konnte zu dem oben genannten Begriff noch keine passende Übersetzung finden. Gelenk-Makrophagen? Ich weiß, was Makrophagen sind, aber "articulaire" irritiert mich hier. Hat das Gelenk seine eigenen Makrohphagen? Plusieurs classes de biomédicaments sont disponibles, ce qui permet d’administrer le plus efficace pour un patient donné selon le profil évolutif de sa polyarthrite rhumatoïde ou les comorbidités associées. La première classe qui a été disponible est celle des anti-TNFalpha, dirigés contre le Tumor Necrosis Factor (TNF) produit par les *macrophages articulaires*. L’excès de TNF déclenche une cascade d’effets anti-inflammatoires néfastes pour les articulations, avec destruction de l’os et dégradation du cartilage. Am Ende des Textes (Patienteninformation) steht folgende Definition, die ja eigentlich den Begriff "macrophages" allein erklärt: Macrophages articulaires : type de cellule du système immunitaire Danke im Voraus für Ideen!	Doris Wolf KudoZ activity Questions: 3061 (11 open) (94 without valid answers) (221 closed without grading) Answers: 222 Germany
synoviale Makrophagen/Makrophagen im Gelenk Explanation: Da es sich um eine Patienteninformation handelt, vielleicht eher "Makrophagen im Gelenk" Bei der chronischen Polyarthritis wird es in großer Menge in den befallenen Gelenken gefunden. Dort wird es im Gelenk von den sogenannten synovialen Makrophagen und Lymphozyten produziert (Synovialis, Synovialmembran = Gelenkinnenhaut; Makrophagen = Zellen, die bei der körpereigenen Abwehr eine wesentliche Rolle spielen; Lymphozyten (ebenfalls Zellen, die bei der körpereigenen Abwehr eine wesentliche Rolle spielen)). https://www.rheuma-online.de/rheuma-online/archiv/fua/antwor... Die Migration von Lymphozyten und Makrophagen im Gelenk führt zum histologischen Bild der beginnenden Synovitis (100). https://refubium.fu-berlin.de/bitstream/handle/fub188/12693/...	Selected response from: Susanne Schiewe Germany Local time: 11:03
Grading comment Vielen Dank! 4 KudoZ points were awarded for this answer

Summary of answers provided
3	synoviale Makrophagen/Makrophagen im Gelenk	Susanne Schiewe

Discussion entries: 2

liz askew United Kingdom 17:06 Mar 31, 2020  by FM Brennan - ‎2002 - ‎Cited by 45 - ‎Related articles 9 May 2002 - These studies have indicated that most cytokines examined are ... of ***TNF-α and IL-1β spontaneously produced by macrophages in the rheumatoid joint*** [4, 5]. ... We have found that TNF-α production in RA synovium is T-cell ... Doris Wolf Germany ASKER 13:55 Mar 31, 2020  Vielen Dank für die ausführliche Antwort! Automatic update in 00:

  

Answers

1 hr   confidence:

synoviale Makrophagen/Makrophagen im Gelenk Explanation: Da es sich um eine Patienteninformation handelt, vielleicht eher "Makrophagen im Gelenk" Bei der chronischen Polyarthritis wird es in großer Menge in den befallenen Gelenken gefunden. Dort wird es im Gelenk von den sogenannten synovialen Makrophagen und Lymphozyten produziert (Synovialis, Synovialmembran = Gelenkinnenhaut; Makrophagen = Zellen, die bei der körpereigenen Abwehr eine wesentliche Rolle spielen; Lymphozyten (ebenfalls Zellen, die bei der körpereigenen Abwehr eine wesentliche Rolle spielen)). https://www.rheuma-online.de/rheuma-online/archiv/fua/antwor... Die Migration von Lymphozyten und Makrophagen im Gelenk führt zum histologischen Bild der beginnenden Synovitis (100). https://refubium.fu-berlin.de/bitstream/handle/fub188/12693/...	Susanne Schiewe Germany Local time: 11:03 Specializes in field Native speaker of: German PRO pts in category: 65
Grading comment Vielen Dank!
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