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affinity maturation

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00:55 Oct 28, 2020
English to Slovenian translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: affinity maturation
Definition from Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.

Example sentence(s):
  • Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. Frontier in Immunology
  • An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. ScienceDirect
  • We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny PNAS
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GBK medical and pharma specialistsGBK medical and pharma specialists


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Summary of translations provided
5afinitetno zorenje
Tomi Dobaj
4zorenje afinitete
Lirka


  

Translations offered


5 hrs   confidence: Answerer confidence 5/5
afinitetno zorenje


Definition from Inštitut za mikrobiologijo in imunologi:
Hkrati z razmnoževanjem poteka tudi preklop med imunoglobulinskimi razredi in afinitetno zorenje limfocitov B. To omogoči razmnoževanje
tistih klonov limfocitov B, ki imajo večjo afiniteto za antigen (pozitivna selekcija), medtem ko kloni z manjšo afiniteto za antigen propadejo.

Example sentence(s):
  • Afinitetno zorenje protiteles s PCR podvrženo napakam in njihova predstavitev na fagih, bakterijah, kvasovkah ali ribosomih, se je že izkazalo za zelo uspešno metodo, ki je pripeljala od 4-1000x izboljšane afinitete vezave. - FKKT UL  
Tomi Dobaj
Slovenia
Local time: 03:18
Native speaker of: Native in SlovenianSlovenian
PRO pts in category: 94
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13 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
zorenje afinitete


Definition from own experience or research:
Zorenje afinitete je proces. pri katerem B celice zorijo in tvorijo protitelesa z večjo afiniteto za antigen in posledično večjo avidnost.

Example sentence(s):
  • In vitro zorenje afinitete rekombinantnih protiteles VHH, specifičnih za 16kDa protein bakterije Mycobacterium tuberculosis - Diplomsko delo na biotehniški fakulteti  
  • Za protitelesa je značilno, da se po prvem stiku z antigenom regije za vezavo teh antigenov na protitelesu še dodatno modificirajo. V tem procesu, ki ga imenujemo tudi zorenje afinitete, nastanejo protitelesa, pri katerih je jakost vezave na antigen tudi ob zgolj rahlih strukturnih prilagoditvah za nekajkrat povečana, kar pomeni učinkovitejši imunski odziv ob ponovnem stiku s kužnim delcem. Nekaj podobnega počnemo ravno pri evoluciji proteinov s predstavitvijo na bakteriofagu. - Intervju s Prof. Dr. Dr. T.Bratkovičem  

Explanation:
Tako izraz uporabljajo strokovnjaki s področja farmacije in biotehnologije. Tudi jezikovno je pravilno.
Lirka
Austria
Local time: 03:18
Native speaker of: Native in EnglishEnglish
PRO pts in category: 16
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