drug dumping

Bulgarian translation: освобождаване на голямо количество лекарство в организма

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:drug dumping
Bulgarian translation:освобождаване на голямо количество лекарство в организма
Entered by: Veta Anton

09:29 Mar 19, 2013
English to Bulgarian translations [PRO]
Science - Biology (-tech,-chem,micro-)
English term or phrase: drug dumping
In fact care should be taken to form a homogenous mixture to avoid the creation of macroscopic areas of high concentrations of the dopamine modulating compound which may result in "drug dumping."
Veta Anton
освобождаване на голямо количество лекарство в организма
Explanation:
Това става от таблетки с удължено (контролирано) освобождаване на лекарството. Вместо постепенно освобождаване на малки количества, в организма се "изхвърля" голяма доза с евентуални лоши последици. За подробности, вж по-долу.

Dose dumping is defined as Unintended, rapid drug release in a short period of time of the entire amount or a significant fraction of the drug contained in a modified release dosage form. A sustained/extended/controlled release dosage form is intended to release the drug in desired concentrations for a prolonged period of time. A dosage form is said to be dose dumped when there is an excess release of drug at a particular time interval other than the stated or required amount. This results in higher systemic drug concentrations that may result in toxicity. This toxicity may be more pronounced or significant in case of drugs with narrow therapeutic window (eg: cardiac glycosides).
http://www.pharmainfo.net/tegkmurthy/blog/dose-dumping-techn...

CURRENTLY AVAILABLE POLYMERS
Currently available polymers for controlled [drug] release can be classified into four major categories: (1) diffusion-controlled systems, (2) … Diffusion-controlled systems are of two types: reservoir and matrix. ……. Another potential problem is that if the reservoir membrane accidentally ruptures, a large amount of drug may be suddenly released into the bloodstream (known as drug dumping).
http://books.google.bg/books?id=PBfLKBTQk0cC&pg=PA79&lpg=PA7...

Drug dumping означава много често изпращане на лекарства (евентуално с изтекал срок на годност) в развиващите се страни

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Note added at 4 hrs (2013-03-19 13:33:03 GMT)
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Това освобождаване на голямо количество лекарство в организма може да се нарече просто (по английски маниер) лекарствен дъмпинг.
Selected response from:

Dimar
Bulgaria
Local time: 19:24
Grading comment
Thanx!
4 KudoZ points were awarded for this answer



Summary of answers provided
5 +1освобождаване на голямо количество лекарство в организма
Dimar
4изхвърляне на медицински отпадъци
Velizara Koleva
Summary of reference entries provided
бързо освобождаване на лекарство в организма
Ivan Klyunchev

  

Answers


18 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
изхвърляне на медицински отпадъци


Explanation:
..


    Reference: http://insineracia.com/%D0%BC%D0%B5%D0%B4%D0%B8%D1%86%D0%B8%...
    Reference: http://www.novini.bg/news/65909-%D0%BD%D0%B0%D0%BA%D0%B0%D0%...
Velizara Koleva
United Kingdom
Local time: 17:24
Native speaker of: Bulgarian
Notes to answerer
Asker: Thanx for the answer, dear colleague!


Peer comments on this answer (and responses from the answerer)
neutral  Ivan Klyunchev: Не се отваря при мен вторият линк. А първият не показва никаква връзка с въпроса.
11 hrs
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3 hrs   confidence: Answerer confidence 5/5 peer agreement (net): +1
освобождаване на голямо количество лекарство в организма


Explanation:
Това става от таблетки с удължено (контролирано) освобождаване на лекарството. Вместо постепенно освобождаване на малки количества, в организма се "изхвърля" голяма доза с евентуални лоши последици. За подробности, вж по-долу.

Dose dumping is defined as Unintended, rapid drug release in a short period of time of the entire amount or a significant fraction of the drug contained in a modified release dosage form. A sustained/extended/controlled release dosage form is intended to release the drug in desired concentrations for a prolonged period of time. A dosage form is said to be dose dumped when there is an excess release of drug at a particular time interval other than the stated or required amount. This results in higher systemic drug concentrations that may result in toxicity. This toxicity may be more pronounced or significant in case of drugs with narrow therapeutic window (eg: cardiac glycosides).
http://www.pharmainfo.net/tegkmurthy/blog/dose-dumping-techn...

CURRENTLY AVAILABLE POLYMERS
Currently available polymers for controlled [drug] release can be classified into four major categories: (1) diffusion-controlled systems, (2) … Diffusion-controlled systems are of two types: reservoir and matrix. ……. Another potential problem is that if the reservoir membrane accidentally ruptures, a large amount of drug may be suddenly released into the bloodstream (known as drug dumping).
http://books.google.bg/books?id=PBfLKBTQk0cC&pg=PA79&lpg=PA7...

Drug dumping означава много често изпращане на лекарства (евентуално с изтекал срок на годност) в развиващите се страни

--------------------------------------------------
Note added at 4 hrs (2013-03-19 13:33:03 GMT)
--------------------------------------------------

Това освобождаване на голямо количество лекарство в организма може да се нарече просто (по английски маниер) лекарствен дъмпинг.


Dimar
Bulgaria
Local time: 19:24
Specializes in field
Native speaker of: Native in BulgarianBulgarian
PRO pts in category: 60
Grading comment
Thanx!
Notes to answerer
Asker: Thanx for the helpful answer, dear colleague!


Peer comments on this answer (and responses from the answerer)
agree  Alpha-Beta
1 hr
  -> Благодаря!

neutral  Ivan Klyunchev: Доколкото разбрах от обясненията, акцентът е по-скоро на бързото освобождаване, дозата е на второ място. За голямо количество съм чувал "ударна доза".
8 hrs
  -> Този акцент не е от преводаческо естество! С ударна доза се започва лечението с антибиотици по предписание на лекаря!
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Reference comments


12 hrs
Reference: бързо освобождаване на лекарство в организма

Reference information:
http://www.google.com/search?hl=en&as_q=уикипедия&as_epq=&as...

Ivan Klyunchev
Bulgaria
Native speaker of: Native in BulgarianBulgarian
PRO pts in category: 28
Note to reference poster
Asker: Thanx for the helpful answer, dear colleague!

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