affinity maturation

Chinese translation: 亲和力成熟

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00:56 Oct 28, 2020
English to Chinese translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: affinity maturation
Definition from Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.

Example sentence(s):
  • Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. Frontier in Immunology
  • An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. ScienceDirect
  • We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny PNAS
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Chinese translation:亲和力成熟
Definition:
抗体亲和力成熟(antibody affinity maturation)是指机体正常存在的一种免疫功能状态。在体液免疫中,再次应答所产生抗体的平均亲和力高于初次免疫应答。这种现象称为抗体亲和力成熟。
Selected response from:

Shaohang Fang
United Kingdom
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4 KudoZ points were awarded for this answer



Summary of translations provided
5 +2亲和力成熟
Shaohang Fang


  

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50 mins   confidence: Answerer confidence 5/5 peer agreement (net): +2
亲和力成熟


Definition from baidubaike:
抗体亲和力成熟(antibody affinity maturation)是指机体正常存在的一种免疫功能状态。在体液免疫中,再次应答所产生抗体的平均亲和力高于初次免疫应答。这种现象称为抗体亲和力成熟。

Example sentence(s):
  • 亲和力成熟是指机体正常存在的一种免疫功能状态。在体液免疫中,再次应答所产生抗体的平均亲和力高于初次免疫应答。这种现象称为抗体亲和力成熟。亲和力是抗体药物的一个关键参数,通常会影响抗体的功能和药效。一般而言,采用杂交瘤细胞技术生成的抗体或者人源化抗体已经具有相对较高的亲和力,但是这种亲和力可能并不足以满足治疗性抗体的需要。目前,药用抗体的研发主要基于杂交瘤细胞或者体外抗体库。 - chemicalbook  
Shaohang Fang
United Kingdom
Local time: 19:35
Native speaker of: Native in ChineseChinese
PRO pts in category: 11

Votes in favor of/against selecting this as the best translation of the term asked
Yes  Renquan Yang: 免疫学标准术语
10 days

Yes  Jie Shen
12 days
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