disease-modifying anti-rheumatic drug (DMARD)

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00:55 May 26, 2020

English to Japanese translations [PRO]
COVID-19 - Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical (general), Journalism

English term or phrase: disease-modifying anti-rheumatic drug (DMARD)

Definition from National Center for Biotechnology Info.:
Disease-modifying antirheumatic drugs (DMARDs) are a class of drugs indicated for the treatment of inflammatory arthritides including rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). They can also be used to in the treatment of other disorders including connective tissue disease such as systemic sclerosis (SSc), systemic lupus erythematosus (SLE), and Sjogren syndrome (SS), as well as in treatment of inflammatory myositis, vasculitis, uveitis, inflammatory bowel disease, and some types of cancers.

Example sentence(s):

Hydroxychloroquine has been available since 1955 as an antimalarial drug. I have at least 6 patients at the pharmacy who have used hydroxychloroquine to manage their rheumatoid arthritis, lupus, and Crohn disease. If you were sitting in my pharmacology class, I’d tell you that it is an antimalarial used as a disease-modifying antirheumatic drug (DMARD). I would tell you it is a cheap drug with good efficacy for some and also that it is 1 of 2 DMARDs that are safe to use in patients with liver failure. You would also learn that it may cause deposition of the drug in the melanin layer of the cones in the retina, underscoring the need for annual eye exams. MJH Life Sciences
DMARDs Not Linked to Poor Outcomes in SARS-CoV-2 RA Patients Rheumatology Network
The analysis of performance measures for rheumatoid arthritis (RA) care have allowed to identify gaps in care that include suboptimal use of disease-modifying anti-rheumatic drugs (DMARDs), according to a study published in Arthritis Care & Research. Rheumatology Advisor

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Summary of translations provided

4 +1

疾患修飾性抗リウマチ薬

Misae Lucasey

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peer agreement (net): +1

疾患修飾性抗リウマチ薬

Definition from 公益社団法人日本薬学会:
疾患修飾性抗リウマチ薬　disease modified anti-rheumatic-drugs

抗リウマチ薬は、疾患修飾抗リウマチ薬（DMARDｓ）とも呼ばれる。抗リウマチ薬は免疫調節薬、免疫抑制薬、生物学的製剤の3つに分類される。免疫調節薬には金化合物(金剤：金チオリンゴ酸ナトリウム、オーラノフィン)、SH基剤(D-ペニシラミン、ブシラミン)、やサラゾスルファピリジンがあり、作用機序は明確ではない。免疫抑制薬であるメトトレキサートは有効性が高くリウマチ治療の標準薬である。生物学的製剤であるインフリキシマブ、アダリムマブ、トシリズマブはモノクローナル抗体で、副作用として感染症があり、専門医のもとで使用される。

Example sentence(s):

本剤のDMARDsとは「Disease Modifying Anti-Rheumatic Drugs（疾患修飾性抗リウマチ薬）」の略称で、関節リウマチの免疫異常を修飾することによって、関節リウマチの活動性をコントロールする薬剤を意味する。 - 日経メディカル処方薬辞典

Misae Lucasey
United States
Local time: 00:04
Native speaker of:

Japanese
PRO pts in category: 4

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