affinity maturation

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00:56 Oct 28, 2020
English to Japanese translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: affinity maturation
Definition from Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.

Example sentence(s):
  • Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. Frontier in Immunology
  • An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. ScienceDirect
  • We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny PNAS
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Summary of translations provided
5親和性成熟
Kayoko Kimura


  

Translations offered


3 days 7 hrs   confidence: Answerer confidence 5/5
親和性成熟


Definition from 大森斉博士による記念講演要�:
親和性の成熟とは、免疫応答で産生される抗体分子がその過程で進化し、抗原に対するより高い親和性を獲得することである。

Example sentence(s):
  • 高親和性抗体を産生する過程は親和性成熟と呼ばれ、液性免疫の重要な機構の一つである。 - 生物工学会誌  
Kayoko Kimura
United States
Local time: 09:40
Native speaker of: Native in JapaneseJapanese
PRO pts in category: 111
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