recombinant antibody

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00:54 Sep 14, 2020
English to Norwegian translations [PRO]
Science - Biology (-tech,-chem,micro-)
Additional field(s): Medical: Pharmaceuticals, Medical (general)
English term or phrase: recombinant antibody
Definition from Pharma IQ:
A Recombinant Antibody is defined as an antibody produced by genetic engineering. Recombinant antibody has significant advantages compared with the conventional antibody and there for its use becoming more popular now days. The fact that no animals are needed in the manufacturing procedure of the recombinant antibodies, in addition, the manufacturing time is relatively short compared with the conventional method. Moreover, the quality of the final product is higher that these of the non recombinant method.

Example sentence(s):
  • By the recombinant DNA technology, link purified genes of VH and VL with prokaryotic expression vector which requires select in advance based on your target recombinant antibody fragments. If you need scfv fragment antibody, linker must be designed in your PCR strategy. Creative Biolabs
  • One of the first recombinant antibody fusions with therapeutic potential consisted of a monoclonal antibody, specific for the fibrin β-chain, in which the Fc portion was replaced with an engineered version of the β-chain of tissue-type plasminogen activator (t-PA) (144). Science Direct
  • Also delivering custom recombinant antibody production, GenScript has invested many years in optimizing its cell lines, gene synthesis and plasmid preparation, transfection reagents, and media systems to offer a suite of different services. Biocompare
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Summary of translations provided
5rekombinant antistoff
Nerissa Lowe


  

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rekombinant antistoff


Definition from own experience or research:
Recombinant antibodies are monoclonal antibodies generated in vitro using synthetic genes.

I have been translating in the pharmaceutical and medical sector for over 20 years.

Example sentence(s):
  • Rekombinant antistoff, anvendelse, fremgangsmate for fremstilling, nukleinsyre, vektor, vertcelle samt farmasoytisk preparat Classifications - Patent NO328687B1  
  • Recombinant antibodies give you the highest level of consistency between batches, peace of mind with an uninterrupted supply, and the ability to engineer sensitivity and specificity. ​​Monoclonal antibodies are typically made using B-cells from an immunized animal to form immortal hybridoma cells that secrete the desired antibody clone. This hybridoma technique produces highly consistent, specific and sensitive monoclonal antibodies in large quantities. However, over time, hybridoma cell lines can experience genetic drift, resulting in slight variations to the antibodies produced. There is also a growing demand for antibodies against difficult targets, ie toxins, nucleotides, and membrane-bound proteins, that can’t always be made with this in vivo model. - Abcam  
  • Recombinant antibodies (rAbs) are produced by cloning antibody genes into expression vectors, which are subsequently introduced into expression hosts to provide animal-free antibody production. By employing genetic engineering methods, it is possible to express light and heavy chains of immunoglobulins as individual proteins, and create a whole set of antibody fragments with improved affinity, stability, and the desired spatial orientation of antigen binding sites or modify potential immunogenicity. The ability to manipulate the genes that encode antibodies (Ab), and thereby manipulate the structures of antibodies, has opened a new era in the study and application of antibodies. - Enzo Life Sciences  

Explanation:
I have translated this term many times over the years.
Nerissa Lowe
United States
Local time: 13:06
Native speaker of: Native in EnglishEnglish
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