unchanged parent enzalutamide

10:07 Mar 5, 2020 

I need to know in Portuguese, But, anyway, thanks

09:29 Mar 5, 2020 

the parent substance is the original substance that was administered (enzalutamide, in this case), without any modifications through metabolization. (In contrast, N-desmethyl enzalutamide would be enzalutimide to which an N-desmethyl group has been added.)

See https://toxtutor.nlm.nih.gov/12-001.html
"Detoxification occurs when biotransformation results in metabolites of lower toxicity. In many cases, however, the metabolites are more toxic than the parent substance, a process called bioactivation."

or

https://www.ncbi.nlm.nih.gov/pubmed/2388874
Allopurinol and caffeine have been used to measure metabolite formation followed by renal elimination of both parent substance and metabolite.

Google "parent substance" for more examples (or try a combination, eg. "parent substance" with "metabolized").