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  3. Medical: Cardiology

targetable

Portuguese translation: mutação Acionável

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:targetable mutation
Portuguese translation: mutação Acionável
Entered by: Lucia Santos

09:07 Mar 7, 2020
English to Portuguese translations [PRO]
Medical - Medical: Cardiology / Medicina - oncologia
English term or phrase: targetable
Estou problemas para achar uma tradução adequada para o termo targetable no excerto:

the majority of patients will not develop a targetable activating mutation

Alguem poderia sugeir algo em português?

Obrigada
Lucia Santos
Brazil
Local time: 19:00
Acionável
Explanation:
Após pesquisa do trecho "Gain-of-function mutations, also called activating mutations" não encontrei outra tradução para activating mutations além de Mutações de ganho de função acionável.

Actionable é sinônimo de Targetable

Some, but not all, driver mutations are also "targetable mutations" or "actionable mutations," which refers to the fact that they can be targeted by a drug.
Selected response from:

Thyago Spring
Brazil
Local time: 19:00
Grading comment
Acredito que para o meu contexto seria acionável mesmo.
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +2orientável/direcionável
Miguel Francisco
4Acionável
Thyago Spring
4 -1segmentável
Erlinda Kofazu
4 -1almejável
Mario Freitas
4 -1desejável
Paulinho Fonseca
3 -1mensurável
Rui Pedro


Discussion entries: 2





  

Answers


8 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +2
orientável/direcionável


Explanation:
Apenas uma sugestão que talvez funcione no contexto.

--------------------------------------------------
Note added at 36 mins (2020-03-07 09:43:57 GMT)
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Realmente, parece que se refere a um "estado propenso" à mutação...

Miguel Francisco
Portugal
Local time: 23:00
Native speaker of: Native in PortuguesePortuguese

Peer comments on this answer (and responses from the answerer)
agree  pedrolmoura: Direcionável é a opção correcta. O termo "targeted mutation" é traduzido como "mutação direcionada"; como tal, "targetable mutation" corresponde a "mutação passível de ser direcionada", ou "direcionável".
3 hrs
agree  Eliane Mello: http://www.informatics.jax.org/glossary/targeted_mutation
1 day 2 hrs
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1 hr   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): -1
segmentável


Explanation:
https://www.ncbi.nlm.nih.gov/pubmed/24327543

Erlinda Kofazu
Brazil
Local time: 19:00
Native speaker of: Native in PortuguesePortuguese

Peer comments on this answer (and responses from the answerer)
disagree  pedrolmoura: Esta opção é incorrecta (explicação do termo no post do Miguel Francisco).
2 hrs
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2 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): -1
almejável


Explanation:
https://www.google.com.br/search?client=firefox-a&hl=en&biw=...

Mario Freitas
Brazil
Local time: 19:00
Native speaker of: Native in EnglishEnglish

Peer comments on this answer (and responses from the answerer)
disagree  pedrolmoura: Esta opção é incorrecta (explicação do termo no post do Miguel Francisco).
1 hr
  -> A opção não é incorreta. Você é que não conhece o termo. Evite usar o "disagree", por favor, a menos que tenha certeza (o que não é o caso aqui)
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2 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): -1
mensurável


Explanation:
Aplicável no contexto

Rui Pedro
Portugal
Local time: 23:00
Works in field
Native speaker of: Native in PortuguesePortuguese

Peer comments on this answer (and responses from the answerer)
disagree  pedrolmoura: Esta opção é incorrecta (explicação do termo no post do Miguel Francisco).
1 hr
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7 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): -1
desejável


Explanation:
Mais uma sugestão.
Você tem o direito do 'disagree' se tiver fundamentos plausíveis para fazê-lo.


    https://www.portalsaofrancisco.com.br/biologia/mutacoes-geneticas
    Reference: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103...
Paulinho Fonseca
Brazil
Local time: 19:00
Native speaker of: Native in PortuguesePortuguese
PRO pts in category: 4

Peer comments on this answer (and responses from the answerer)
disagree  pedrolmoura: "Desejável" refere-se ao potencial efeito de uma mutação para o organismo em si (em inglês "desirable" ou "beneficial"). Neste caso, as mutações que causam resistência são indesejáveis mas podem potencialmente ser anuladas (ou não) com um dado tratamento.
47 mins
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16 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
Acionável


Explanation:
Após pesquisa do trecho "Gain-of-function mutations, also called activating mutations" não encontrei outra tradução para activating mutations além de Mutações de ganho de função acionável.

Actionable é sinônimo de Targetable

Some, but not all, driver mutations are also "targetable mutations" or "actionable mutations," which refers to the fact that they can be targeted by a drug.

Example sentence(s):
  • the majority of patients will not develop a targetable activating mutation
  • a maioria dos pacientes não desenvolve mutações de ganho de função acionável

    https://en.wikipedia.org/wiki/Mutation#By_effect_on_function
    https://www.verywellhealth.com/lung-cancer-with-an-egfr-mutation-4097338
Thyago Spring
Brazil
Local time: 19:00
Specializes in field
Native speaker of: Portuguese
PRO pts in category: 4
Grading comment
Acredito que para o meu contexto seria acionável mesmo.
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