declare failure of beta-blockade
Russian translation: [не] считать бета-блокаду отсутствующей
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| 12:08 Feb 9, 2021 |
| English to Russian translations [PRO] Medical - Medical: Health Care | |||||||
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|  Selected response from: Lesia Kutsenko Canada Local time: 07:24 | ||||||
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| 4 +1 | не обнаруживается неэффективность блокады бета-адренорецепторов |
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| 3 | [не] считать бета-блокаду отсутствующей |
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| 3 | * |
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| Discussion entries: 1 | |
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Answers
10 mins confidence: 
[не] считать бета-блокаду отсутствующей Explanation: -------------------------------------------------- Note added at 1 hr (2021-02-09 13:12:19 GMT) -------------------------------------------------- Доза препарата должна быть минимальной, при которой облегчаются симптомы, но не следует считать бета-блокаду отсутствующей до тех пор, пока не будут выявлены ее физиологические свидетельства (т.е. подавление ЧСС в покое) |
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Notes to answerer
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2 hrs confidence: peer agreement (net): +1
peer agreement (net): +1не обнаруживается неэффективность блокады бета-адренорецепторов Explanation: или "не обнаруживается недостаточная блокада бета-адренорецепторов" |
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1 day 20 hrs confidence:
* Explanation: увеличивать дозу до улучшения целевой симптоматики, но без возникновения побочных эффектов, которые потребуют отмены терапии (т. е. укажут на неудачный выбор дозировки терапии бета-блокаторами) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481297/ Beta blockers should be initiated at low doses and titrated slowly to target doses if tolerable (Table 1). Adverse events include fluid retention and worsening HFrEF, fatigue, bradycardia or heart block, and hypotension. The fluid retention or worsening HFrEF associated with beta blockers do not generally warrant the permanent withdrawal of treatment. Beta-blocker-induced bradycardia is generally asymptomatic and thus requires no treatment; however, if the bradycardia is accompanied by dizziness, lightheadedness, or second- or third-degree heart block, the dose of the beta blocker should be decreased. |
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