Myeloablation

Russian translation: Миелоабляция

16:30 Jan 14, 2021
English to Russian translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: Myeloablation
These back-up cells will be given to your son if the genetically-modified stem cells do not multiply after being re-injected into your son’s body.
If we determine that a sufficient quantity of hematopoietic stem cells cannot be obtained, your child will be excluded from participation in the research study.
After 10 years, the remaining supply of stored back-up cells will be destroyed if the doctor determines that they are no longer clinically relevant for your child.
Once the gene transfer is complete, the Lenti-D drug product manufactured for your son will be frozen and tests will be carried out to make sure that the product meets acceptable criteria to be re-injected.
If the Lenti-D drug product is acceptable, the rest of the management will take place in the hospital.
In this case, the study doctor will discuss other possible options with you.
*Myeloablation* (treatment): administration of busulfan and fludarabine
Within a few days before the start of treatment, your son will have different exams (see exam table in Appendix A) to determine if he is still eligible to participate in the study.
Among these exams, a behavioral assessment, a quality-of-life questionnaire and a neuropsychological exam will be carried out by a qualified test administrator or by your child, depending on the test.
Your son will be hospitalized during and after receiving the medication for a few weeks, depending on how his body recovers after receiving the medication.
Busulfan and fludarabine are chemotherapy drugs that eliminate the remaining blood stem cells within the bone marrow in order to “make room” for the genetically-modified cells that will be re-injected into your child’s body.
Maxim Polukhin
Local time: 14:18
Russian translation:Миелоабляция
Explanation:
Миелоабляция

Полное или почти полное подавление кроветворения после высокодозной химиотерапии и/или лучевой терапии.
https://www.mdspatient.ru/home/slovar-terminov



--------------------------------------------------
Note added at 11 мин (2021-01-14 16:42:19 GMT)
--------------------------------------------------

"Было проведено исследование,где β$gal+ MAPCs вводили мышам с иммунодефицитом, кото$рым не проводилась миелоабляция".

https://www.sogaz-clinic.ru/upload/iblock/413/kletochnye-i-g...

"Лимитирующим фактором такого метода лечения является токсичность, связанная с необратимыми повреждениями кроветворного костного мозга (миелоабляция)"ю

https://medicknow.com/bookstudent/burmester-imunologiya/30.p...

--------------------------------------------------
Note added at 12 мин (2021-01-14 16:43:13 GMT)
--------------------------------------------------

Извините за опечатки.
Selected response from:

Landsknecht
Ukraine
Local time: 13:18
Grading comment
Спасибо!
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +2Миелоабляция
Landsknecht


  

Answers


9 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +2
myeloablation
Миелоабляция


Explanation:
Миелоабляция

Полное или почти полное подавление кроветворения после высокодозной химиотерапии и/или лучевой терапии.
https://www.mdspatient.ru/home/slovar-terminov



--------------------------------------------------
Note added at 11 мин (2021-01-14 16:42:19 GMT)
--------------------------------------------------

"Было проведено исследование,где β$gal+ MAPCs вводили мышам с иммунодефицитом, кото$рым не проводилась миелоабляция".

https://www.sogaz-clinic.ru/upload/iblock/413/kletochnye-i-g...

"Лимитирующим фактором такого метода лечения является токсичность, связанная с необратимыми повреждениями кроветворного костного мозга (миелоабляция)"ю

https://medicknow.com/bookstudent/burmester-imunologiya/30.p...

--------------------------------------------------
Note added at 12 мин (2021-01-14 16:43:13 GMT)
--------------------------------------------------

Извините за опечатки.

Landsknecht
Ukraine
Local time: 13:18
Native speaker of: Native in RussianRussian, Native in UkrainianUkrainian
PRO pts in category: 146
Grading comment
Спасибо!

Peer comments on this answer (and responses from the answerer)
agree  Doctor Alex
26 mins
  -> Спасибо!

agree  Lesia Kutsenko
3 hrs
  -> Спасибо!
Login to enter a peer comment (or grade)



Login or register (free and only takes a few minutes) to participate in this question.

You will also have access to many other tools and opportunities designed for those who have language-related jobs (or are passionate about them). Participation is free and the site has a strict confidentiality policy.

KudoZ™ translation help

The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.


See also:
Term search
  • All of ProZ.com
  • Term search
  • Jobs
  • Forums
  • Multiple search