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linker scanning mutagenesis

Spanish translation: mutagénesis por escaneo de conectores

07:41 May 31, 2017
English to Spanish translations [PRO]
Science - Biology (-tech,-chem,micro-) / Molecular Biology Patent
English term or phrase: linker scanning mutagenesis
Hi,

Could you help me with this term? I give you the complete sentence:

Linker scanning mutagenesis, particularly in a combinatorial setting, is an attractive method for identifying truncated (bioactive) forms of the MTM1 polypeptide.

I do not know the right translation: mutagénesis por escaneo del vinculador/enlazador??

Thanks...
Cris Legarda
Spain
Local time: 13:59
Spanish translation:mutagénesis por escaneo de conectores
Explanation:
los 'conectores' (linkers) son oligonucleótidos sintéticos que se utilizan para unir secuencias o mantener propiedades de la cadena de nucleótidos.
En realidad es un método para localizar regiones importantes para alguna función. En lugar de mutar individualmente los nucleótidos y ver los efectos, se introducen 'cadenitas' de secuencia conocida (los conectores) y se observan los efectos.
El método fue desarrollado por McKnight y Kingsbury para estudiar las señales de control de la transcripción de un gen determinado de un virus.

http://www.biology-online.org/dictionary/Linker_scanning
Linker scanning
a type of deletion mutagenesis where the distance and/or reading frame between potentially important regions is maintained by replacement with a synthetic oligonucleotide of known sequence.
Selected response from:

David Balayla
Spain
Local time: 13:59
Grading comment
Muchas gracias David y compañía! Al final el cliente me dijo que eligiera yo el término más adecuado y me quedé con este. Mil gracias.
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +2mutagénesis por escaneo de conectores
David Balayla


Discussion entries: 2





  

Answers


1 hr   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +2
mutagénesis por escaneo de conectores


Explanation:
los 'conectores' (linkers) son oligonucleótidos sintéticos que se utilizan para unir secuencias o mantener propiedades de la cadena de nucleótidos.
En realidad es un método para localizar regiones importantes para alguna función. En lugar de mutar individualmente los nucleótidos y ver los efectos, se introducen 'cadenitas' de secuencia conocida (los conectores) y se observan los efectos.
El método fue desarrollado por McKnight y Kingsbury para estudiar las señales de control de la transcripción de un gen determinado de un virus.

http://www.biology-online.org/dictionary/Linker_scanning
Linker scanning
a type of deletion mutagenesis where the distance and/or reading frame between potentially important regions is maintained by replacement with a synthetic oligonucleotide of known sequence.


    Reference: http://www.biology-online.org/dictionary/Linker_scanning
    Reference: http://what-when-how.com/molecular-biology/linker-scanning-m...
David Balayla
Spain
Local time: 13:59
Specializes in field
Native speaker of: Native in EnglishEnglish, Native in SpanishSpanish, Native in CatalanCatalan
PRO pts in category: 12
Grading comment
Muchas gracias David y compañía! Al final el cliente me dijo que eligiera yo el término más adecuado y me quedé con este. Mil gracias.
Notes to answerer
Asker: Gracias, David. Lo de "linkers" era mi mayor duda, y se la he preguntado el cliente, porque los llaman de diversas maneras: conectores, vinculadores, enlazadores,... vamos, que sinceramente no se cuál es la mejor.


Peer comments on this answer (and responses from the answerer)
agree  Hernan Casasbuenas: De acuerdo con David, creo que la mejor opción es conectores
4 hrs
agree  Pablo Cruz
1 day 2 hrs
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