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affinity maturation

Spanish translation: Maduración de (la) afinidad

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00:55 Oct 28, 2020
English to Spanish translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: affinity maturation
Definition from Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.

Example sentence(s):
  • Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. Frontier in Immunology
  • An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. ScienceDirect
  • We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny PNAS
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Question posted on behalf of translation team:
GBK medical and pharma specialistsGBK medical and pharma specialists


This question is closed

Spanish translation:Maduración de (la) afinidad
Definition:
La maduración de afinidad es un proceso que tiene lugar durante la respuesta primaria frente a un antígeno proteico y que consiste en el aumento de afinidad en los anticuerpos producidos contra dicho antígeno.

Se lleva a cabo por medio de la selección de aquellos linfocitos B que, tras un proceso de hipermutación somática en los genes que codifican para la región variable de las inmunoglobulinas, expresan en la membrana receptores de alta afinidad para el antígeno.
Selected response from:

María C Turri
Argentina
Grading comment
4 KudoZ points were awarded for this answer



Summary of translations provided
4 +4Maduración de (la) afinidad
María C Turri


  

Translations offered


2 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +4
Maduración de (la) afinidad


Definition from Clínica Universidad de Navarra:
La maduración de afinidad es un proceso que tiene lugar durante la respuesta primaria frente a un antígeno proteico y que consiste en el aumento de afinidad en los anticuerpos producidos contra dicho antígeno.

Se lleva a cabo por medio de la selección de aquellos linfocitos B que, tras un proceso de hipermutación somática en los genes que codifican para la región variable de las inmunoglobulinas, expresan en la membrana receptores de alta afinidad para el antígeno.

Example sentence(s):
  • Efectivamente, de las numerosas variantes aleatorias que van surgiendo en los linfocitos B de los centros germinales, algunas son de mayor afinidad que la original, y otras serán de menor afinidad. A partir de ahí, el antígeno dirige un proceso selectivo que va enriqueciendo las poblaciones de linfocitos B con inmunoglobulinas de mayor afinidad; proliferan más aquellos linfocitos con versiones de Ig de mayor afinidad (y quizá también de mejor cinética). Este fenómeno es lo que se conoce como maduración de la afinidad. - Universidad de Granada, España  
María C Turri
Argentina
Local time: 11:21
Native speaker of: Native in SpanishSpanish
PRO pts in category: 95

Votes in favor of/against selecting this as the best translation of the term asked
Yes  elmejor: Yes
1 day 2 hrs
Yes  Diana Cortes
1 day 8 hrs
Yes  Leda Roche
1 day 18 hrs
Yes  pkeimel: Sí, es correcto.
2 days 15 hrs
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