skalowanie syntezy
| 15:32 Sep 20, 2015 |
| Polish to English translations [PRO] Medical - Medical: Pharmaceuticals | |||||||
|---|---|---|---|---|---|---|---|
|
| ||||||
| Summary of answers provided | ||||
|---|---|---|---|---|
| 3 | scaling-up synthesis/synthesis scale-up |
| ||
| 2 | large-scale synthesis |
|
| Summary of reference entries provided | |||
|---|---|---|---|
| Ciekawe artykuły |
|
| Discussion entries: 5 | |
|---|---|
Answers
32 mins confidence: 
large-scale synthesis Explanation: Textbook of Drug Design and Discovery, Fourth Edition, page 6 "Planning a large-scale synthesis and initiation of formulation studies. Textbook of Drug Design and Discovery, Fourth Edition https://books.google.hu/books?isbn=1439882401 - Oldal lefordítása Kristian Stromgaard, Povl Krogsgaard-Larsen, Ulf Madsen - 2009 - Medical ... in order to elucidate mode of action, efficacy, acute and chronic toxicity, and ... Planning of large scale synthesis and initiation of formulation studies. ... Phase III clinical studies, which involve studies of range of efficacy and long-term and rare ... Prehistoric drug discovery started with higher plant and animal substances, ... chronic toxicity study on animals |
| |
| Login to enter a peer comment (or grade) | ||
1 hr confidence:
scaling-up synthesis/synthesis scale-up Explanation: Scaling up synthesis of new drugs on pilot plant ... https://www.linkedin.com/pub/david-voisin/5/351/a36 ccccccccccccccccccccccccc We have considered the high cost of developing and producing this drug, and the ... began in the spring of 1985, as did work on scaling up synthesis of the drug. https://archive.org/stream/aidsissueshearin00unit/aidsissues... cccccccccccccccccccc . drug candidates; (3) establishing library for drug discovery; (4) scaling up synthesis; (5) developing new methods of green chemistry with high atom economy. https://www.molport.com/shop/supplier/Nowa-Pharmaceuticals-C... ccccccccccccc that employ chemists such as the pharma giants like GlaxoSmithKline/Pfizer/etc (novel synthses of drug molecules, scaling up synthesis to an industrial scale, http://www.thenakedscientists.com/forum/index.php?topic=1810... ccccccccccccccccccccccccccccccccc Drug design – pharmacokinetic harmacokinetics ... Drugs must have both hydrophilic and must have ...... Optimization and scaling up synthesis http://www.mch.estranky.sk/file/280/03ab_drug-development-fi... ccccccccccccccccccccccccccccccccccc .. Scaling up synthesis from gram quantities to kilograms is essential for drug development, .. http://jchps.com/pdf/v5/is3/5_3 Article 3 page 92-97.pdf cccccccccccccccccccccccccccc Scaling up synthesis and quality control of targeted drug delivery http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088482/ ccccccc to produce a virtually infinite number of rationally designed QS-21 analogs. ... to further develop TiterQuil-1-0-5-5 for clinical use by scaling up synthesis in an ... 2 SBIR application supporting a TiterQuil-1-0-5-5 drug master file (DMF) and its http://grantome.com/grant/NIH/R43-AI114030-01 -------------------------------------------------- Note added at 3 hrs (2015-09-20 18:48:06 GMT) -------------------------------------------------- Outsourcingowa chemia medyczna Od niedawna podobną tendencję można zauważyć także w zakresie chemii medycznej – firmy farmaceutyczne wykorzystują źródła zewnętrzne do poszukiwaniu nowych substancji leczniczych. Skąd wziął się wzrost popularności outsourcingu, czyli wykorzystania zewnętrznych firm (CRO – contract research organization) w tej gałęzi przemysłu? Do lat 90. XX wieku strategia outsourcingu była wykorzystywana przez firmy farmaceutyczne głównie w celu końcowego określenia profilu potencjalnego leku w późnej fazie przedklinicznej. Obecnie przedsiębiorstwom zewnętrznym można zlecić cały proces projektowania leków od A do Z, choć najczęściej zakontraktowane prace obejmują rutynowe i czasochłonne procesy, m.in. skalowanie syntezy czy syntezę półproduktów. Dzięki takim rozwiązaniom odciążeni zostają „rdzenni” chemicy, którzy swój czas mają poświęcić na tworzenie nowych molekuł i optymalizację cząsteczki. http://www.e-bmp.pl/farmacja/od-hitu-po-badania-przedklinicz... |
| |
| Login to enter a peer comment (or grade) | ||
Reference comments
1 hr |
| Reference: Ciekawe artykuły Reference information: The Medicinal Chemistry Division applies modern synthetic methods and principles to design and synthesize novel compounds for biological evaluation as potential drugs. The chemical compounds produced are optimized in an iterative process of synthesis followed by evaluation in a battery of assays to produce a clinical candidate with appropriate pharmacological, pharmacokinetic and toxicological properties. The Medicinal Chemistry Division also synthesizes reference compounds, modified drugs for improved drug delivery (pro-drugs), specialized excipients for drug delivery, specialized reagents for the modification targets of biological origin, radiolabeled compounds, larger GLP batches of development candidates for pre-clinical toxicology and formulation studies. Capabilities and Expertise Medicinal Chemistry: Rational drug design and synthesis of analogs Library synthesis (automated platform) Targeted structure-activity relationships Lead optimization - See more at: http://www.cdrd.ca/about-us/facilities-and-expertise/medicin... http://www.cdrd.ca/about-us/facilities-and-expertise/medicin... SCALE-UP (nieco podobne konteksty) LINK NADRZĘDNY: https://www.google.pl/#q=synthesis scaling innovative drugs Ps. Nie znam się na chemii za bardzo- w tym doskonały jest Kuba- zatem kilka linków - może między wierszami coś się znajdzie- jakieś ukierunkowanie. |
| |
| Login to enter a peer comment (or grade) | ||
Login or register (free and only takes a few minutes) to participate in this question.
You will also have access to many other tools and opportunities designed for those who have language-related jobs (or are passionate about them). Participation is free and the site has a strict confidentiality policy.
KudoZ™ translation help
The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.
See also:
Search millions of term translations