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English to Spanish: Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack General field: Medical
Source text - English Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack
Transient ischemic attack (TIA) and acute minor ischemic stroke are common and often lead to disabling events. In China, there are approximately 3 million new strokes every year, and approximately 30% of them are minor ischemic strokes. The incidence of TIA in China has not been determined, but on the basis of the incidence in other countries, there are probably more than 2 million TIAs annually in China. The risk of another stroke occurring after a TIA or minor stroke is high, with approximately 10 to 20% of patients having a stroke within 3 months after the index event; most of these strokes occur within the first 2 days.
The role of antiplatelet therapy for secondary stroke prevention has been well established. However, aspirin is the only antiplatelet agent that has been studied in the acute phase of stroke, during which its benefit is modest. Aspirin and clopidogrel synergistically inhibit platelet aggregation, and such dual therapy reduces the risk of recurrent ischemic events in patients with the acute coronary syndrome. Large-scale trials of secondary prevention of ischemic events after stroke have not shown a benefit of the combination of clopidogrel and aspirin. However, these trials did not study the early, high-risk period after stroke, they included some patients with strokes of moderate severity, and they included few if any patients with TIA. Three small pilot trials have shown trends toward a benefit of the combination therapy and minimal safety concerns in patients with minor stroke or TIA.
Translation - Spanish Combinación de clopidogrel y aspirina en pacientes con ictus isquémico menor o ataque isquémico transitorio
El ataque isquémico transitorio (AIT) y el ictus isquémico menor se producen con frecuencia y a menudo provocan lesiones incapacitantes. En China se producen aproximadamente 3 millones de ictus nuevos al año y, aproximadamente, el 30 % de ellos son ictus isquémicos menores. Aunque no se ha establecido con exactitud la incidencia del AIT en China, teniendo en cuenta la incidencia en otros países, lo más probable es que se produzcan más de 2 millones de AIT en ese país cada año. El riesgo de sufrir otro ictus después de un AIT o un ictus menor es elevado ya que, aproximadamente entre el 10 % y el 20 % de los pacientes que los padecen, sufren otro ataque antes de los 3 meses posteriores al episodio inicial; la mayoría de ellos se producen en los dos primeros días. Aunque se ha consolidado el tratamiento con antiagregantes plaquetarios para la prevención de nuevos ictus, la aspirina es el único antiagregante plaquetario que se ha estudiado en la fase aguda de los ataques, momento en el que sus beneficios son reducidos. La aspirina y el clopidogrel inhiben de forma sinérgica la agregación plaquetaria reduciendo el riesgo de sufrir nuevos ataques isquémicos en pacientes con síndrome coronario agudo. No se ha conseguido demostrar el beneficio de la combinación de clopidogrel y aspirina a través de ensayos a gran escala sobre la prevención secundaria de ataques isquémicos después de un ictus. Sin embargo, estos ensayos no analizaron las fases de alto riesgo que se dan después de los ataques, sino que incluían pacientes con ictus de gravedad moderada y estudiaron a unos cuantos o a ningún paciente con AIT. Tres pequeños ensayos han demostrado que el tratamiento combinado tiende a ser beneficioso y seguro en pacientes con ictus menores o AIT.
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Bachelor's degree - Universidad de Sevilla
Experience
Years of experience: 17. Registered at ProZ.com: Oct 2004. Became a member: Oct 2014.
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English (Universidad de Sevilla, verified) English to Spanish (Universidad de Sevilla)
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Adobe Acrobat, Microsoft Excel, Microsoft Word, OmegaT, Castcradle, Snagit, Webbudget, WinHTTrack, Passolo, Powerpoint, Swordfish, Trados Studio
I am an English-Spanish freelance translator with more than eight years of experience working in different translation fields such as IT, international institutions, etc. I am specialized in web translation and localization (adaption of products or services to a given language and culture).
Keywords: English, Spanish, translation, localization, software, web, IT, medical
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