Glossary entry (derived from question below)
English term or phrase:
smooth plasma metformin peak and trough levels
Spanish translation:
regulan/controlan los niveles plasmáticos máximos y mínimos de metformina
Added to glossary by
Margarita Ezquerra (Smart Translators, S.L.)
Sep 24, 2014 04:24
9 yrs ago
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English term
Also an Engineer
Native in: Spanish (Variant: Venezuelan)
Works in: English to Spanish, Spanish to English, Spanish
smooth plasma metformin peak and trough levels
English to Spanish
Medical
Medical (general)
Estoy traduciendo un artículo titulado "Safety, tolerability, and efficacy of metformin extended-release oral antidiabetic therapy in patients with type 2 diabetes: An observational trial in Asia".
"Absorption of MIR occurs predominantly in the upper GI tract, with peak serum concentrations achieved within 3 h. Although it remains unknown how metformin causes GI side-effects, extended-release
metformin (MXR) formulations that delay time to peak metformin plasma concentrations and **smooth
plasma metformin peak and trough levels** may lead to improved tolerability compared with MIR."
MIR = immediate-release metformin
peak and trough levels = concentraciones máximas y mínimas
¿A qué se refiere "smooth" aquí?
Gracias nuevamente
"Absorption of MIR occurs predominantly in the upper GI tract, with peak serum concentrations achieved within 3 h. Although it remains unknown how metformin causes GI side-effects, extended-release
metformin (MXR) formulations that delay time to peak metformin plasma concentrations and **smooth
plasma metformin peak and trough levels** may lead to improved tolerability compared with MIR."
MIR = immediate-release metformin
peak and trough levels = concentraciones máximas y mínimas
¿A qué se refiere "smooth" aquí?
Gracias nuevamente
Proposed translations
(Spanish)
| 2 | regulan/controlan los niveles plasmáticos máximos y mínimos de metformina |
Margarita Ezquerra (Smart Translators, S.L.)
|
Change log
Sep 30, 2014 07:32: Margarita Ezquerra (Smart Translators, S.L.) Created KOG entry
Proposed translations
3 hrs
Margarita Ezquerra (Smart Translators, S.L.)
Spain
Spain
Native in Spanish
Spain
Margarita Ezquerra (Smart Translators, S.L.)
Accredited translators 20 yrs experience
Native in: Spanish
Works in: English to Spanish, Spanish to English, French to Spanish
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924
Selected
regulan/controlan los niveles plasmáticos máximos y mínimos de metformina
Sanofi Cepatin XR | Sanofi Diabetes India
www.sanofidiabetes.in/cepatin-doctor.aspx
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17/9/2013 - It slows the rate of glucose production through a reduction in hepatic gluconeogenesis. .... by smoothing the peaks and troughs in plasma Metformin ... The oral bioavailability of Metformin is in the range of 40 to 60% ...
The Synergistic Effect of Miglitol Plus Metformin ...
care.diabetesjournals.org/content/24/6/989.long - Traducir esta página
de JL Chiasson - 2001 - Citado por 78 - Artículos relacionados
Maintaining normal plasma glucose levels is a key factor in reducing the risk of ..... reported previously to smooth and lower postprandial plasma glucose peaks (8, 9, ... and metformin reduce plasma glucose levels through completely different ...
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Comment: "Mil gracias"
Reference comments
20 hrs
Marcelo de las Heras
Argentina
Argentina
Native in Spanish
Specializes in field
Argentina
Related KudoZ points
:
59
Reference:
Se refiere a que al ser una formulación de liberación má lenta y por ende extendida en el tiempo, el pico de concentración plasmática que se alcanza es menos abrupto o agudo, resultando en una forma más "suave" o alisada del pico. Al alcanzarse una concentración máxima menor, los efectos adversos son también supuestamente menos frecuentes.
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