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actionable

Russian translation: терапевтически значимые мутации/мутации-мишени таргетной терапии

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:actionable
Russian translation:терапевтически значимые мутации/мутации-мишени таргетной терапии
Entered by: Margarita Vidkovskaia

15:01 Sep 19, 2020
English to Russian translations [PRO]
Medical - Medical (general) / Cancer, Genetics
English term or phrase: actionable
Дана схема с разными генами, мутации которых приводят к раку легкого, и соответствующими методами терапии. В одном блоке написано "no actionable alterations". Скриншот: https://i.imgur.com/L6l8y9P.png

Думаю о варианте "практически значимые", но не уверен, насколько это выражение подходит.

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The new buzzword in personalized cancer medicine is “actionable mutation”. This label is given to the genetic aberrations that are present in some patients’ tumors, and that are intended targets of new drugs.
https://bioethics.georgetown.edu/2015/09/acting-on-actionabl...

An actionable mutation is defined as a genetic aberration in the DNA (e.g., activating mutation) when detected in a patient’s tumor, and would be expected or predicted to affect a response to a targeted treatment available in basket or umbrella clinical trials, FDA-approved treatments, or be available for off-label treatment.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140098/
lerethel
Russian Federation
Local time: 16:20
терапевтически значимые мутации/мутации-мишени таргетной терапии
Explanation:
терапевтически значимые мутации
мутации-мишени таргетной терапии
Selected response from:

Margarita Vidkovskaia
Russian Federation
Local time: 16:20
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
4потенциально восприимчивый
Iryna Bulanova
4терапевтически значимые мутации/мутации-мишени таргетной терапии
Margarita Vidkovskaia
3значимые (мутации)
Natalia Novichenko


Discussion entries: 1





  

Answers


3 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
потенциально восприимчивый


Explanation:
Группа ученых из нескольких ведущих американских университетов, включая Институт Броуда при Массачусетском технологическом институте и Гарвардском университете, совместно с аспирантом из Университета ИТМО выявила ряд драйверных генетических мутаций в клетках рака легких, которые могут быть успешно подвержены таргетированным и иммунным терапиям.

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Note added at 3 hrs (2020-09-19 18:41:31 GMT)
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No actionable alterations-
Потенциально-восприимчивых мутаций не обнаружено.


    Reference: http://https://news.itmo.ru/ru/news/5632/
Iryna Bulanova
United States
Local time: 08:20
Specializes in field
Native speaker of: Russian
PRO pts in category: 8
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17 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
значимые (мутации)


Explanation:
Еще нашла такой вариант в русскоязычном интернете. Очень важно знать мнение коллег, так как сама сейчас перевожу текст с таким определением мутаций

Example sentence(s):
  • http://www.niboch.nsc.ru/lib/exe/fetch.php/ru/events/defence/%D0%BA%D0%B5%D1%87%D0%B8%D0%BD_%D0%B0%D0%B2%D1%82%D0%BE%D1%80%D0%B5%D1%84%D0%B5%D1%80%D0%B0%D1%82.pdf
  • http://cancergenome.ru/mutations/BRCA1_2/
Natalia Novichenko
Ukraine
Local time: 16:20
Specializes in field
Native speaker of: Native in UkrainianUkrainian
PRO pts in category: 71
Login to enter a peer comment (or grade)

1 day 2 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
терапевтически значимые мутации/мутации-мишени таргетной терапии


Explanation:
терапевтически значимые мутации
мутации-мишени таргетной терапии


    https://ascopubs.org/doi/full/10.1200/PO.19.00017#:~:text=A%20gene%20is%20considered%20actionable,select%20alteration%20or%20tumor%20types.
Margarita Vidkovskaia
Russian Federation
Local time: 16:20
Specializes in field
Native speaker of: Native in RussianRussian
PRO pts in category: 1396
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