Dec 25, 2020 18:37
3 yrs ago
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English term
Neq, nicotine equivalents
English to Polish
Medical
Chemistry; Chem Sci/Eng
Found in an article about the effects of using heat-not-burn tobacco products.
"To describe nicotine exposure, in addition to plasma levels of nicotine and cotinine, nicotine equivalents (Neq) were determined as the molar sum of free nicotine, nicotine-glucuronide, free cotinine, cotinine-glucuronide, free trans-30-hydroxycotinine, and trans-30-hydroxycotinine-glucuronide in urine (expressed as concentration adjusted for creatinine)."
"To describe nicotine exposure, in addition to plasma levels of nicotine and cotinine, nicotine equivalents (Neq) were determined as the molar sum of free nicotine, nicotine-glucuronide, free cotinine, cotinine-glucuronide, free trans-30-hydroxycotinine, and trans-30-hydroxycotinine-glucuronide in urine (expressed as concentration adjusted for creatinine)."
Discussion
Zetknąłem się z określeniem "ekwiwalent czystej nikotyny" (PNE = Pure Nicotine Equivalent). Nie wiem, czy to jest to samo.
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Jeśli chodzi o procentowy udział poszczególnych metabolitów w wydalaniu nikotyny około 90% przyjętej dawki alkaloidu jest wydalane z moczem
- http://www.wbc.poznan.pl/Content/180113/index.pdf - page 25