aclaramientos

English translation: vacuolization/vacuoles

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Spanish term or phrase:aclaramientos (biopsia)
English translation:vacuolization/vacuoles
Entered by: Yvonne Becker

22:14 Nov 9, 2022
Spanish to English translations [PRO]
Medical - Medical (general) / biopsia
Spanish term or phrase: aclaramientos
En un informe de una biopsia de próstata:

"Aproximadamente el 70 % de los fragmentos muestran tumor con características de adenocarcinoma prostático pobremente diferenciado, el cual entremezcla componente tumoral de ductos grandes y de ductos pequeños acinares. La lesión neoplasia en algunas áreas focales muestra necrosis centrando la proliferación celular en ductos grandes de patrón comedociano. Las células proliferantes en gran parte son grandes, de citoplasma atenuado y basofílico y núcleos con severa anaplasia; muestran reforzamiento de la membrana nuclear, **aclaramientos** y nucléolos prominentes con actividad mitótica baja."

No entiendo qué son estos "aclaramientos", salvo que se refiera a zonas claras en las muestras (?). No he logrado dar con ningún equivalente en inglés que cuadre dentro del contexto. ¿Alguien me puede echar una mano? Muchísimas gracias por adelantado
Yvonne Becker
Local time: 09:55
vacuolization/vacuoles
Explanation:
Aclaramiento o vacuolización: En este contexto, se refiere a alteraciones de la morfología celular observadas en la microscopía de una muestra de tejido.

Ref:

Vacuolización: Espacios en el citoplasma por la digestión enzimática de las organelas.

Lesión Celular - FFyB
http://www.ffyb.uba.ar › files › muerte-celular-8944

Los tumores apocrinos se caracterizan por aspectos citológicos tales como abundante citoplasma
granular eosinofílico,*** vacuolización o aclaramiento citoplásmico***, núcleos vesiculares redondos…
DC_Egu%EDaLarreaM_Pron%F3sticoReceptoresAndr%F3genosCancerdeMamaMARTA.pdf;jsessionid=BF3BD7F9C3BBD899978E748AB8530965 (usal.es)
Citoplasma: Amplio y variable. Las células pueden presentar un citoplasma granular eosinófilo (Tipo I), un citoplasma con aclaramiento o vacuolización perinuclear (Tipo II) y un citoplasma vacuolizado o balonizado (Tipo III).
http://www.conganat.org/seap/congresos/2003/seminariocitolog...

Vacuoles in acinar adenocarcinoma of the prostate
Adenocarcinomas of the prostate may contain clear vacuoles and these should be distinguished from true signet-ring carcinomas which contain mucin.
https://www.humpath.com/spip.php?article18645
The following patterns were tabulated: (1) intraductal growth pattern (IDC), (2) prominent vacuolization of tumor cells, (3) inconspicuous appearance of collapsed tumor glands, (4) cribriform architecture, and (5) inconspicuous appearance of cancer cells (cancer cells that if viewed at relatively low magnification, eg, ×40 final magnification, might be easily overlooked).
https://academic.oup.com/ajcp/article/133/4/654/1761396
Selected response from:

María Patricia Arce
Argentina
Local time: 10:55
Grading comment
Muchísimas gracias
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +2vacuolization/vacuoles
María Patricia Arce
3clearance
William Hepner


  

Answers


27 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
clearance


Explanation:
They could be referring to the phenomenon of measuring the volume of plasma removed from a specific substance over a certain period of time, possibly in this case in the context of the prostate, called "clearance" in English and "depuración" or "aclaramiento" in Spanish.

Definition of clearance: "Clearance is the pharmacokinetic measurement of the volume of plasma that is removed of a specific substance over a period of time."

In Spanish: "Aclaramiento es un término usado en farmacocinética para describir el volumen de plasma que queda completamente libre de una sustancia por unidad de tiempo."

Example sentence(s):
  • Clearance is the pharmacokinetic measurement of the volume of plasma that is removed of a specific substance over a period of time.

    https://www.sciencedirect.com/topics/medicine-and-dentistry/renal-clearance
    https://toolbox.eupati.eu/glossary/aclaramiento/?lang=es
William Hepner
United States
Local time: 09:55
Native speaker of: Native in EnglishEnglish
PRO pts in category: 16
Login to enter a peer comment (or grade)

1 hr   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +2
vacuolization/vacuoles


Explanation:
Aclaramiento o vacuolización: En este contexto, se refiere a alteraciones de la morfología celular observadas en la microscopía de una muestra de tejido.

Ref:

Vacuolización: Espacios en el citoplasma por la digestión enzimática de las organelas.

Lesión Celular - FFyB
http://www.ffyb.uba.ar › files › muerte-celular-8944

Los tumores apocrinos se caracterizan por aspectos citológicos tales como abundante citoplasma
granular eosinofílico,*** vacuolización o aclaramiento citoplásmico***, núcleos vesiculares redondos…
DC_Egu%EDaLarreaM_Pron%F3sticoReceptoresAndr%F3genosCancerdeMamaMARTA.pdf;jsessionid=BF3BD7F9C3BBD899978E748AB8530965 (usal.es)
Citoplasma: Amplio y variable. Las células pueden presentar un citoplasma granular eosinófilo (Tipo I), un citoplasma con aclaramiento o vacuolización perinuclear (Tipo II) y un citoplasma vacuolizado o balonizado (Tipo III).
http://www.conganat.org/seap/congresos/2003/seminariocitolog...

Vacuoles in acinar adenocarcinoma of the prostate
Adenocarcinomas of the prostate may contain clear vacuoles and these should be distinguished from true signet-ring carcinomas which contain mucin.
https://www.humpath.com/spip.php?article18645
The following patterns were tabulated: (1) intraductal growth pattern (IDC), (2) prominent vacuolization of tumor cells, (3) inconspicuous appearance of collapsed tumor glands, (4) cribriform architecture, and (5) inconspicuous appearance of cancer cells (cancer cells that if viewed at relatively low magnification, eg, ×40 final magnification, might be easily overlooked).
https://academic.oup.com/ajcp/article/133/4/654/1761396


María Patricia Arce
Argentina
Local time: 10:55
Specializes in field
Native speaker of: Native in SpanishSpanish
PRO pts in category: 96
Grading comment
Muchísimas gracias

Peer comments on this answer (and responses from the answerer)
agree  neilmac: Vacuoles and nucleoles...
8 hrs
  -> Thank you, Neil

agree  liz askew
12 hrs
  -> Thank you, Liz6
Login to enter a peer comment (or grade)



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