Glossary entry (derived from question below)
English term or phrase:
gene silencing
Croatian translation:
"stišavanje" gena
Feb 9, 2010 13:57
14 yrs ago
English term
gene silencing
GBK
English to Croatian
Science
Biology (-tech,-chem,micro-)
Definition from
MedicineNet, Inc.:
Gene silencing: A mechanism by which cells shut down large sections of chromosomal DNA. Gene silencing is done by incorporating the DNA to be silenced into a form of DNA called heterochromatin that is already silent.
The process of gene silencing is important for the differentiation of many different types of cells.
Example sentences:
Evidence is emerging that geminiviruses and plant pararetroviruses can interact with the gene silencing system either from introduced DNA constructs or during viral pathogenesis. Some observations suggest there are complex relationships between DNA viral activity, transcriptional and post-transcriptional gene silencing mechanisms. (biotech-info.net)
The biggest challenges in the field at the moment are understanding two things: how does DNA methylation participate in gene silencing (and that includes what molecules target the DNA methylation to these promoter regions), and why is the cancer cell doing this? (The Thomson Corporation)
In 2005, Pikaard and his collaborators published research showing that the major function of Pol IV is to generate siRNAs, thereby singling out this RNA polymerase as a potential player in gene silencing. (ScienceDaily LLC)
Proposed translations
(Croatian)
| 5 +2 | "stišavanje" gena |
PeregrineFalcon
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| 5 | utišavanje gena |
Dinap
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Change log
Feb 9, 2010 13:00: changed "Kudoz queue" from "In queue" to "Public"
Feb 9, 2010 13:58: changed "Stage" from "Preparation" to "Submission"
Feb 12, 2010 15:04: changed "Stage" from "Submission" to "Selection"
Feb 18, 2010 08:54: changed "Stage" from "Selection" to "Completion"
Proposed translations
+2
15 mins
Selected
"stišavanje" gena
Definition from
Vjesnik:
Razvitak tehnika poput<br />interferencije RNK koja omoguæava<br />stišavanje gena koji<br />potièu bolesti i starenje, pokazala<br />je da se medicina transformirala<br />u informacijsku<br />tehnologiju, istièe šezdesetogodišnji<br />Kurzweil.
Example sentences:
Craig Mello Izvor: Wikipedija Craig Cameron Mello (rođen 18. listopada 1960.) je američki biolog koji je 2006.g. dobio Nobelovu nagradu za fiziologiju ili medicinu zajedno sa Andrew Fireom za njihovo otkriće RNK interferencije (engl. RNA interference - RNAi) - stišavanja gena (engl. gene silencing) dvostrukom RNK. (Wikipedija)
Ključne reči: mijelodisplastični sindrom, hipermetilacija DNA, stišavanje gena, inhibitori DNA metiltransferaze Key words: Myelodysplastic syndrome. DNA hypermethylation, Gene silencing (Medicina danas)
Tim postupcima se neznatno mijenja genom (ukupna količina gena) ili se postojeći gen "pojačava" ili "stišava" da bi se dobilo željeno svojstvo unutar vrste. (Coolinarika)
4 KudoZ points awarded for this answer.
18 mins
utišavanje gena
Definition from
own experience or research:
To je metoda inaktivacije određenih gena kem. modifikacijama u svrhu izmjene njihove ekspresije u eukariota
Example sentences:
Utišavanje nekih gena u tumorima povezano je s pojačanom metilacijom u CpG otocima u regulatornim dijelovima tih gena. S obzirom da se u promotoru i prvom eksonu gena za Cx26 nalazi velik broj CpG dinukleotida, ispitivali smo povezanost ekspresije Cx26 i metilacije te regije gena. (Znanstveni rad_Hrv. znan.bibliografija)
Rezultati opisani u našem radu jasno pokazuju korisnost RNA interferencije kao metode za utišavanje gena u istraživanju raka, te pridonose razvoju in vitro modela za buduću gensku terapiju tumora. (znanstveni rad_hrv.znan. bibliografija)
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