Oct 28, 2020 00:56
3 yrs ago
20 viewers *
English term
affinity maturation
GBK
English to Portuguese
Medical
Medical (general)
Definition from
Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.
Example sentences:
Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. (Frontier in Immunology)
An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. (ScienceDirect)
We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny (PNAS)
Proposed translations
(Portuguese)
| 4 +3 | maturação de afinidade |
Liane Lazoski
|
Change log
Oct 3, 2020 00:42: changed "Kudoz queue" from "In queue" to "Public"
Oct 28, 2020 00:56: changed "Stage" from "Preparation" to "Submission"
Oct 31, 2020 01:57: changed "Stage" from "Submission" to "Completion"
Proposed translations
+3
8 hrs
Liane Lazoski
Brazil
Brazil
Brazil
Certified and Certifying
Native in: English 
, Portuguese (Variant: Brazilian) 
Works in: English to Portuguese, Spanish to Portuguese, Portuguese to English, and 3 more.
Related KudoZ points
:
4
Selected
maturação de afinidade
Definition from
Wikipedia:
A maturação de afinidade (em inglês affinity maturation) é um processo do sistema imunológico de mamíferos, cujo resultado é a melhora da eficiência da resposta imune em um segundo contato com um antígeno.
Example sentences:
A maturação da afinidade é o processo pelo qual a afinidade dos anticorpos produzidos em resposta a um antígeno proteico aumenta com a exposição prolongada ou repetida a esse antígeno. (Passei direto)
- Rede neural Booleana com processos de crescimento, poda e atualização de pesos inspirados no princípio da seleção clonal e maturação de afinidade (Unicamp)
A resposta humoral frente a Ag proteicos requer o reconhecimento do antígeno pelos LT auxiliares e sua cooperação com os LB antígeno-específicos, estimulando a expansão clonal dos LB, a mudança de classe, a maturação de afinidade e a diferenciação em LB de memória. (Scielo)
4 KudoZ points awarded for this answer.
Something went wrong...