Oct 28, 2020 00:54
3 yrs ago
4 viewers *
English term
affinity maturation
GBK
English to Serbian
Medical
Medical (general)
Definition from
Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.
Example sentences:
Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. (Frontier in Immunology)
An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. (ScienceDirect)
We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny (PNAS)
Change log
Oct 3, 2020 00:38: changed "Kudoz queue" from "In queue" to "Public"
Oct 28, 2020 00:54: changed "Stage" from "Preparation" to "Submission"
Oct 31, 2020 01:56: changed "Stage" from "Submission" to "Selection"
Nov 7, 2020 01:55:
Nov 27, 2020 01:55:
Dec 27, 2020 03:09: