nadir of the peripheral wbc count

Spanish translation: concentración mínima de leucocitos en sangre periférica

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English term or phrase:	nadir of the peripheral wbc count
Spanish translation:	concentración mínima de leucocitos en sangre periférica
Entered by:	Yvonne Becker

23:56 Jan 25, 2016

English to Spanish translations [PRO]
Medical - Medical: Cardiology

English term or phrase: nadir of the peripheral wbc count

Estoy traduciendo un estudio titulado "Hypersensitivity Reactions to i.v. Melphalan during Treatment of Multiple Myeloma: Cancer and Leukemia Group B Experience".

"Melphalan (L-PAM) has long been used as a first-line drug in the treatment of multiple myeloma. In several large series reporting the use of oral L-PAM, no allergic reactions were reported except for the rare occurrence of a skin rash (1-4). Between 1971 and 1977, i.v. L-PAM was used in three completed randomized studies of multiple myeloma sponsored by Cancer and Leukemia Group B (CALGB) (protocol Nos. 7161, 7261, and 7461). Informed consent was obtained prior to patient entry in each study. Figure 1 shows the treatment programs for each of the three studies containing i.v. L-PAM. L.-PAM was initially dissolved in 10% ethanol and diluted to concentration of 10 mg/ml in normal saline and injected slowly (1-2 minutes) directly i.v. or into the tubing of a running i.v. infusion. In all three trials, one group of patients was randomized to receive oral L-PAM (0.15 mg/kg/day for 7 days. with a maintenance dose of 0.05 mg/kg/day after recovery from the **nadir of the peripheral wbc count**) together with an initial 6-10-week course of oral prednisone in tapering doses."

WBC = white blood count (por lo que el "count" de la expresión está de más)
L-PAM = melfalán

Según Navarro, nadir se refiere a "a la concentración mínima registrada en una serie temporal de determinaciones. En el ámbito médico se usa sobre todo referido a la cifra mínima de linfocitos T CD4 registrada en un paciente con sida antes de iniciar el tratamiento antirretrovírico; en ese caso, considero mucho más claro y preciso decir ‘cifra mínima de linfocitos’ que *nadir de linfocitos*"

Puede que aquí se refiere a la cifra mínima de linfocitos después de un tratamiento con melfalán, pero quisiera corroborarlo, además de saber a qué se refiere "peripheral" en este contexto.

Un millón de gracias

Yvonne Becker KudoZ activity Questions: 4266 (3 open) (3 without valid answers) (73 closed without grading) Answers: 2174
Local time: 12:14

nadir del recuento leucocitario periférico

Explanation:
Cuando hable sobre los efectos secundarios de la quimioterapia, escuchará con frecuencia la palabra "nadir", principalmente con referencia a los recuentos sanguíneos
http://chemocare.com/es/chemotherapy/what-is-chemotherapy/na...

El recuento leucocitario periférico, la VSG y la PCR suelen estar aumentados, aunque en ocasiones la PCR es normal...
http://apps.elsevier.es/watermark/ctl_servlet?_f=10&pident_a...

Selected response from:

Robert Carter
Mexico
Local time: 10:14

Grading comment

Gracias a todos
4 KudoZ points were awarded for this answer

Summary of answers provided

3 +2

nadir del recuento leucocitario periférico

Robert Carter

Summary of reference entries provided

peripheral WBC count

Robert Carter

Discussion entries: 2

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50 mins confidence:

peer agreement (net): +2

nadir del recuento leucocitario periférico

Robert Carter
Mexico
Local time: 10:14
Native speaker of:

English
PRO pts in category: 4

Grading comment

Gracias a todos

Reference comments

43 mins peer agreement (net): +1

Reference: peripheral WBC count

Reference information:
WBC count =white blood **cell** count.

Peripheral blood cells are the cellular components of blood, consisting of red blood cells (erythrocytes), white blood cells (leucocytes), and platelets, which are found within the circulating pool of blood and not sequestered within the lymphatic system, spleen, liver, or bone marrow.
https://en.wikipedia.org/wiki/Peripheral_blood_cell

Robert Carter
Mexico
Native speaker of:

English
PRO pts in category: 4

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nadir of the peripheral wbc count

Spanish translation: concentración mínima de leucocitos en sangre periférica

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nadir of the peripheral wbc count

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