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Glossary entry

German term or phrase:

titerstark

English translation:

high titer

Added to glossary by David Williams
Nov 13, 2009 16:58
14 yrs ago
German term

titerstark

German to English Science Biology (-tech,-chem,micro-)
Context:

"PRODUKT" ist ein titerstarkes ... Streptavidin-Biotin-System.

Cf. http://tinyurl.com/yzjbow3

Although the reagent we are talking about is mentioned there, there is no mention of titration. It simply states that this is a traditional detection system reformulated for rapid IHC.
Proposed translations (English)
3 +2 high titer
4 highly-sensitive [assay]
References
Titer

Discussion

MMUlr Nov 13, 2009:
They want to emphasize ... that this assay is rather powerful, potent, etc. in that it can detect the specific antibody (?) or marker or whatever even when the concentration is really low. So titerstark -> high titer in a way is leading astray.
Zareh Darakjian Ph.D. Nov 13, 2009:
reference on streptavidin-biotin system http://www.clinchem.org/cgi/reprint/37/5/625
Zareh Darakjian Ph.D. Nov 13, 2009:
You may be right, David.. and I may be wrong. David You may be right. It appears that the system you have , streptavidin is a system where the two have the capability of binding to each other. So, high titration signal might be the correct term ... even though a wider context might help in being sure of this.
Zareh Darakjian Ph.D. Nov 13, 2009:
David: In the reference that you give, "titration signal" is used to mean that there was a high concentration of "antibody-antigen"- type recognition. When this happens on a large scale, it is said that the binding is specific and strong as evidenced by a high titration signal. Here the titration signal is a measure of "recognition". I don't think that's the context here. I think here we are talking about a "high titer" or high concentration strptavidin-biotin system.
David Williams (asker) Nov 13, 2009:
Could it mean it "has a strong titration signal"?
Cf. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519404/

Proposed translations

+2
18 mins
Selected

high titer

http://www.nature.com/mt/journal/v3/n4/abs/mt200183a.html

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Note added at 20 mins (2009-11-13 17:19:12 GMT)
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or high-titer, probably better. The meaning is that there is a high
concentration or "load" of streptavidin.. in my opinion. Titer, in chemistry is equivalent to concentration. Of course, the implication is that this concentration is determined through a titration process.

This titration process can also be done on biological systems.

--------------------------------------------------
Note added at 22 mins (2009-11-13 17:20:30 GMT)
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http://www.answers.com/topic/titer

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Note added at 23 mins (2009-11-13 17:22:11 GMT)
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also n.
Concentration of a substance in solution or the strength of such a substance determined by titration.
The minimum volume needed to cause a particular result in titration.
Peer comment(s):
agree MMUlr : You are right IMO regarding the meaning of titer in this laboratory context, see also: -> http://jco.ascopubs.org/cgi/content/abstract/15/11/3363 (I will add a note in the discussion field .... not enough space here!).
32 mins
Thank you, Doctor. You are right, as I also realized the point you make after I gave my answer...
agree Harald Moelzer (medical-translator)
2 days 13 hrs
Thank you, Harald.
Something went wrong...
4 KudoZ points awarded for this answer. Comment: "Many thanks!"
1 day 2 hrs

highly-sensitive [assay]

usually, sensitivity denotes the ability to potently detect something....antibody, etc.
Something went wrong...

Reference comments

22 mins
Reference:

Titer

Titer
[frz. titre, eigtl. »Angabe eines (Mischungs)verhältnisses«] der, -s/-, Chemie: in der Maßanalyse das Verhältnis der tatsächlichen Konzentration an wirksamem Reagenz in einer Titrierlösung c(X) zum Sollwert der Konzentration c(X). Der Faktor t=c(X)/c(X) wird durch Titration gegen eine Urtitersubstanz ermittelt; bei einer Lösung, die gegenüber dem Sollwert 1-normal z.B. den Wert 1,1-normal hat, beträgt der Titer 1,1.
©Bibliographisches Institut & F. A. Brockhaus AG, Mannheim; Spektrum Akademischer Verlag GmbH, Heidelberg, 2003
Peer comments on this reference comment:
agree Rolf Keiser
42 mins
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