Oct 10, 2010 12:34
13 yrs ago
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English term

corneal kindling

English to Russian Medical Medical (general)
ххх was tested in several models predictive of anticonvulsant efficacy, such as the maximal electroshock seizure test in the rat and mouse and corneal kindling in mice.

Proposed translations

49 mins
Selected

провоцирование припадков/конвульсий (судорог) посредством повторной/многократной стимуляции роговицы

Дословно kindling - это "разжигание". В данной модели при провоцировании эпилептических припадков (обычно посредством электрической стимуляции) длительность и степень последующих припадков увеличиваются: говорят о снижении порога. В дальнейшем даже подпороговое воздействие может спровоцировать припадок.
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4 KudoZ points awarded for this answer.
7 mins

прижигание роговицы



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Note added at 10 mins (2010-10-10 12:45:22 GMT)
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Kindling-like effect induced by repeated corneal electroshock in mice.

Sangdee P, Turkanis SA, Karler R.
Abstract

The present study demonstrates that with the use of corneal electrodes mice can be kindled to minimal convulsions by repeated 60-Hz electroshocks. The efficacy of kindling was found to be dependent upon several stimulus parameters, including duration and intensity as well as the intertrial interval. Because the complexity and generalization of the minimal convulsions increased with the number of electroshock treatments, it was apparent that such kindling had quantitative as well as qualitative characteristics. Moreover, the fact that 50% of the mice remained completely kindled to minimal convulsions 8 weeks after cessation of repeated stimulation indicated that the phenomenon is relatively long-lived. Finally, the increase in CNS excitability associated with kindling extended to some, but not all, chemo- and electroshock tests of excitability. Altogether, the results show that mice kindled by corneal electrode stimulation have many features in common with animals kindled by stimulation of discrete brain areas. Because the procedure can readily and rapidly yield large numbers of kindled animals, an important application for the method will be in the evaluation of drug effects on kindled animals.
http://www.ncbi.nlm.nih.gov/pubmed/7140663

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Note added at 11 mins (2010-10-10 12:46:10 GMT)
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Или "электростимуляция роговицы"
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1 hr

корнеальный(роговичный) клиндинг

Киндлинг (раскачка) представляет собой феномен, когда повторяющаяся субконвульсивная стимуляция определенных областей мозга приводит к прогрессирующему развитию судорожной активности.

Киндлинг - вполне самостоятельный термин, что даёт возможность не использовать описательный перевод.

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Note added at 1 час (2010-10-10 14:30:12 GMT)
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Опечатка, конечно - киндлинг.
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