Mar 16, 2017 12:09
7 yrs ago
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English term
Capizzi style methotrexate
English to Spanish
Medical
Medical (general)
Informed consent - clinical trial
El texto pertenece a un formulario de consentimiento para participar en un ensayo clínico sobre la leucemia.
This includes high dose methotrexate during Interim Maintenance I and ***Capizzi style methotrexate*** during Interim Maintenance.
***Capizzi-Style Methotrexate*** with Pegasparagase (C-MTX) Is Superior to High-Dose Methotrexate (HDMTX) in T-Lineage Acute Lymphoblastic Leukemia (T-ALL): Results from Children's Oncology Group (COG).
What is escalating dose methotrexate?
Escalating dose means that they start with 100 mg/m2 and raise the dose by 50 mg/m2 until toxicity is apparent, meaning that the ANC goes down or mucositis is apparent. The methotrexate is given every 10 days. This is called ***"Capizzi I methotrexate"*** and was a component of previous trials, CCG 1961 (arms C/D) and POG 9906, during interim maintenance. The augmented arms of CCG 1961 (arms C/D) proved to give the highest EFS (this information is published as abstracts on the Blood Journal web site, ASH, 2004; click on the ASH (American Society of Hematology) link on the right - ASH Annual Meeting Abstracts. Then click on the 2004 annual meeting abstracts.)
Se refiere a "Metotrexato estilo/tipo Capizzi"?
Muchas gracias!
This includes high dose methotrexate during Interim Maintenance I and ***Capizzi style methotrexate*** during Interim Maintenance.
***Capizzi-Style Methotrexate*** with Pegasparagase (C-MTX) Is Superior to High-Dose Methotrexate (HDMTX) in T-Lineage Acute Lymphoblastic Leukemia (T-ALL): Results from Children's Oncology Group (COG).
What is escalating dose methotrexate?
Escalating dose means that they start with 100 mg/m2 and raise the dose by 50 mg/m2 until toxicity is apparent, meaning that the ANC goes down or mucositis is apparent. The methotrexate is given every 10 days. This is called ***"Capizzi I methotrexate"*** and was a component of previous trials, CCG 1961 (arms C/D) and POG 9906, during interim maintenance. The augmented arms of CCG 1961 (arms C/D) proved to give the highest EFS (this information is published as abstracts on the Blood Journal web site, ASH, 2004; click on the ASH (American Society of Hematology) link on the right - ASH Annual Meeting Abstracts. Then click on the 2004 annual meeting abstracts.)
Se refiere a "Metotrexato estilo/tipo Capizzi"?
Muchas gracias!
Proposed translations
(Spanish)
| 4 | metotrexato (administrado) como parte del régimen Capizzi |
Mónica Belén Colacilli
|
| 2 +2 | metotrexato Capizzi |
Neil Ashby
|
Proposed translations
17 mins
Mónica Belén Colacilli
Argentina
Argentina
Native in Spanish
Specializes in field
Argentina
Translator since 2003, Medicine Student
Native in: Spanish (Variants: Argentine, Latin American) 
Works in: English to Spanish, Spanish to English, Spanish
Related KudoZ points
:
94
Selected
metotrexato (administrado) como parte del régimen Capizzi
Hola Gaby.
Se trata de una pauta terapéutica (o régimen) en se que se utiliza metotrexato. No encuentro referencias en español, pero esa sería mi traducción.
Aquí pego un párrafo de la referencia citada:
Methotrexate is part of standard chemotherapy for children with ALL. It is usually given with asparaginase (Cristanaspase, Elspar, L-Asnase), a combination called the Capizzi regimen that starts with low doses of methotrexate that gradually increase over time. This regimen reduces the risk that the disease will come back in the bone marrow, but does not decrease recurrences in the central nervous system (CNS; the brain and spinal cord). To lower CNS recurrences, researchers compared high-dose methotrexate (doses 50 times higher than the starting dose used for the Capizzi regimen) with the standard Capizzi regimen for patients between the ages of one and 30 with newly-diagnosed ALL
Espero te sea de ayuda.
Saludos,
Mónica
Se trata de una pauta terapéutica (o régimen) en se que se utiliza metotrexato. No encuentro referencias en español, pero esa sería mi traducción.
Aquí pego un párrafo de la referencia citada:
Methotrexate is part of standard chemotherapy for children with ALL. It is usually given with asparaginase (Cristanaspase, Elspar, L-Asnase), a combination called the Capizzi regimen that starts with low doses of methotrexate that gradually increase over time. This regimen reduces the risk that the disease will come back in the bone marrow, but does not decrease recurrences in the central nervous system (CNS; the brain and spinal cord). To lower CNS recurrences, researchers compared high-dose methotrexate (doses 50 times higher than the starting dose used for the Capizzi regimen) with the standard Capizzi regimen for patients between the ages of one and 30 with newly-diagnosed ALL
Espero te sea de ayuda.
Saludos,
Mónica
4 KudoZ points awarded for this answer.
Comment: "Perfecto, muchas gracias! Saludos."
+2
6 mins
Neil Ashby
Spain
Spain
Native in English
Specializes in field
Spain
DrNeil TechTrans, Precision & Clarity
Native in: English
Works in: Spanish to English, English
Related KudoZ points
:
287
metotrexato Capizzi
I don't think that "style" really bares any significance.
Leucemia linfoblástica aguda infantil: Tratamiento (PDQ®)—Versión ...
https://www.cancer.gov/espanol/tipos/.../tratamiento-lla-inf...
Translate this page
Nov 21, 2016 - Los pacientes se asignaron al azar para recibir dosis altas de metotrexato o dosis en aumento de metotrexato IV (metotrexato Capizzi) durante ...
Dexametasona y metotrexato en dosis altas mejora el resultado en ...
www.univadis.es/.../Dexametasona-y-metotrexato-en-dosis-alt...
Translate this page
Metotrexato en dosis altas es superior a metotrexato Capizzi para el tratamiento de la leucemia linfoblástica aguda de linfocitos B de riesgo alto, sin aumento de ...
Leucemia linfoblástica aguda infantil: Tratamiento (PDQ®)—Versión ...
https://www.cancer.gov/espanol/tipos/.../tratamiento-lla-inf...
Translate this page
Nov 21, 2016 - Los pacientes se asignaron al azar para recibir dosis altas de metotrexato o dosis en aumento de metotrexato IV (metotrexato Capizzi) durante ...
Dexametasona y metotrexato en dosis altas mejora el resultado en ...
www.univadis.es/.../Dexametasona-y-metotrexato-en-dosis-alt...
Translate this page
Metotrexato en dosis altas es superior a metotrexato Capizzi para el tratamiento de la leucemia linfoblástica aguda de linfocitos B de riesgo alto, sin aumento de ...
Peer comment(s):
| agree |
Marta Casals
: Sí, yo también lo dejaría así
36 mins
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Gracias Marta, un saludo
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| agree |
Pablo Cruz
21 hrs
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Gracias y saludos Pablo.
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