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  3. Medical: Pharmaceuticals

*two-way* crossover study

German translation: Zweifach-Crossover-Studie

09:45 Feb 23, 2024
English to German translations [PRO]
Medical - Medical: Pharmaceuticals / Title of a clinical study
English term or phrase: *two-way* crossover study
My problem is the term "Two-way", which didn't yet happen to me, and research is quite frustrating. The only german translation to be found is from US websites ("Zwei-Wege-Crossover"), most likely MT-translated. No correspondence in German resources. I found 2 descriptions of the procedure in EN, talking about 2 different "groups" being confronted.
They didn't use the term "treatment arm", though to me this seemed the most logical interpretation.
Anybody can confirm "Crossover-Studie mit 2 Behandlungsarmen" or has already experience with this concrete term??
Thanks a lot in advance.



Extracts from the Synopsis:

- This is a randomized, open-label, ***two-way*** crossover, single-dose bioequivalence study comparing two "XXX" oral formulations (suspension vs. capsules) in patients with malignant glioma.

- Participants will be randomly assigned in a 1:1 ratio to one of the two formulation sequences (test suspension - reference capsules [T-R], or reference capsules - test suspension [R-T]), to be received on Day 1 and Day 2. On Day 3, participants will resume/start treatment with standard of care temozolomide and will be discharged.

- To test bioequivalence in a ***two-treatment, two-sequence, two-period study*** with 90% power, assuming an expected ratio between test and reference PK parameter means ranging from...
Peter Eckschmidt MD
Italy
Local time: 12:37
German translation:Zweifach-Crossover-Studie
Explanation:
Das ist die Verkürzung des zitierten "two-treatment, two-sequence, two-period". Theoretisch könnte man an den beiden Behandlungsgruppen ja auch mehr als zwei Behandlungen hintereinander testen (was statistisch vermutlich allerdings sinnlos wäre). Weitere Verwendungsbeispiele lassen sich ergoogeln.

(Ich hatte auch mal mit einer "3-way crossover study", also einer Dreifach-Crossover-Studie, zu tun, mit drei Behandlungsgruppen, die die gleichen drei Behandlungen in drei unterschiedlichen Reihenfolgen erhielten.)
Selected response from:

Dr. Matthias Schauen
Germany
Local time: 12:37
Grading comment
Vielen Dank für die schnelle Antwort, Matthias!
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +1Zweifach-Crossover-Studie
Dr. Matthias Schauen
3Cross-Over-Studie mit Intra- und Intergroupvergleich, auch 2x2 Crossover-Studie
Lirka


Discussion entries: 3





  

Answers


3 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
Zweifach-Crossover-Studie


Explanation:
Das ist die Verkürzung des zitierten "two-treatment, two-sequence, two-period". Theoretisch könnte man an den beiden Behandlungsgruppen ja auch mehr als zwei Behandlungen hintereinander testen (was statistisch vermutlich allerdings sinnlos wäre). Weitere Verwendungsbeispiele lassen sich ergoogeln.

(Ich hatte auch mal mit einer "3-way crossover study", also einer Dreifach-Crossover-Studie, zu tun, mit drei Behandlungsgruppen, die die gleichen drei Behandlungen in drei unterschiedlichen Reihenfolgen erhielten.)

Example sentence(s):
  • Zusätzlich wurde die Wirkung einer oralen Einzeldosis Lorlatinib (50 mg, 75 mg und 100 mg) mit und ohne Itraconazol mit einer Dosis von 200 mg einmal täglich in einer Zweifach-Crossover-Studie an 16 gesunden Probanden untersucht.

    https://figi.pfizer.de/sites/default/files/FI-22462.pdf
Dr. Matthias Schauen
Germany
Local time: 12:37
Meets criteria
Specializes in field
Native speaker of: Native in GermanGerman
PRO pts in category: 244
Grading comment
Vielen Dank für die schnelle Antwort, Matthias!

Peer comments on this answer (and responses from the answerer)
agree  Steffen Walter
1 day 21 hrs
Login to enter a peer comment (or grade)

1 day 18 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
Cross-Over-Studie mit Intra- und Intergroupvergleich, auch 2x2 Crossover-Studie


Explanation:
https://support.minitab.com/de-de/minitab/21/help-and-how-to...

Lirka
Austria
Local time: 12:37
Does not meet criteria
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 12
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