Glossary entry (derived from question below)
English term or phrase:
switch control kinase inhibitor
Italian translation:
inibitore del controllo di switch della chinasi
English term
Portugal
Translation, proofreading, editing, MTPE
Native in: Italian 
Works in: English to Italian, Arabic to Italian, Portuguese to Italian, and 3 more.
switch control kinase inhibitor
| 4 | inibitore del controllo di switch della chinasi |
Gaetano Silvestri Campagnano
|
Proposed translations
Italy
Quality, accuracy and reliability
Native in: Italian (Variants: Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, Standard-Italy, 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Works in: English to Italian, French to Italian, Spanish to Italian
inibitore del controllo di switch della chinasi
https://www.gistsupport.org/ask-the-professional/switch-pock...
"The “switch pocket” is an area on KIT and other kinases that is adjacent to the ATP pocket. The “switch pocket” binds to the activation loop which acts as the major “on-off switch” of a kinase. The kinase will be active or “on” when the “activation loop switch” is bound to the “switch pocket”. By preventing the “switch” from binding to the “switch pocket,” a switch pocket inhibitor can prevent a kinase from turning “on” or can even turn “off” an already active kinase."
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Note added at 50 min (2020-11-12 11:30:55 GMT)
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Agisce in pratica su questa sorta di "interruttore" proteico della chinasi.
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Note added at 51 min (2020-11-12 11:32:09 GMT)
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Ecco un altro riferimento:
https://www.deciphera.com/science/our-kinase-switch-control-...
"Our proprietary drug discovery Kinase Switch Control platform is based on our deep insight into the biology of kinases. The transformation of a kinase from an inactive to an activated state is dependent upon the interaction of one region of the kinase called the activation switch with an area called the switch pocket; a mechanism of activation that is common among kinases. By directly targeting the switch pocket, we design inhibitors to be broadly active against the target kinase, covering both wild-type and many or all of the known mutant or amplified forms, or spectrum-selective towards several chosen kinases."
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Note added at 56 min (2020-11-12 11:37:15 GMT)
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Puoi anche scrivere:
inibitore dell'interruttore della chinasi
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Note added at 57 min (2020-11-12 11:37:45 GMT)
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Con o senza virgolette.
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Note added at 1 ora (2020-11-12 11:50:23 GMT)
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Ecco un riferimento in italiano:
https://blog.farmaciavirtuale.it/2013/11/inibitori-delle-chi...
"In questo articolo commenteremo, in via generale, l’attività degli inibitori delle tirosin e serin/treonin chinasi. Volendo semplificare il concetto di chinasi, potremmo descriverle come enzimi ATP dipendenti, che funzionano da interruttori della cellula."
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Note added at 7 giorni (2020-11-19 12:43:18 GMT) Post-grading
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Grazie mille a te, Vincenzo. A presto e buona giornata!
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